A second middle eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9

S M Leal; F Apaydin; C Barnwell; M Iber; T Kandogan; M Pfister; U Braendle; O Cura; M Schwalb; H P Zenner; E Vitale

doi:10.1038/sj.ejhg.5200201

A second middle eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9

Eur J Hum Genet. 1998 Jul-Aug;6(4):341-4. doi: 10.1038/sj.ejhg.5200201.

Authors

S M Leal¹, F Apaydin, C Barnwell, M Iber, T Kandogan, M Pfister, U Braendle, O Cura, M Schwalb, H P Zenner, E Vitale

Affiliation

¹ Laboratory of Statistical Genetics, Rockefeller University, New York, USA. lealsm@rockvax.rockefeller.edu

Abstract

A second kindred has been identified which supports the previously reported location of DFNB9. Linkage has been established to markers closely linked to DFNB9 which is located on 2p22-p23. The hearing impaired individuals in this highly consanguineous kindred from Eastern Turkey have prelingual profound hearing loss which affects all frequencies. A genetic map of the 2p22-p23 region where DFNB9 resides was generated using marker genotypes available from the CEPH database. All markers were placed on this genetic map using a likelihood ratio criterion of 1000:1. This map suggests that the region for DFNB9 is less than 1.08 cM, 95% confidence interval (0-2.59 cM).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping
Chromosomes, Human, Pair 2
Deafness / genetics*
Female
Genes, Recessive*
Genetic Linkage
Genotype
Hereditary Sensory and Autonomic Neuropathies / genetics*
Humans
Male
Middle East
Pedigree

Abstract

Publication types

MeSH terms

Grants and funding