Abstract
We present a review of limb development integrating current molecular information and selected genetic disorders to illustrate the advances made in this field over the last few years. With this knowledge, clinical geneticists can now begin to consider molecular mechanisms and pathways when investigating patients with limb malformation syndromes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bone Development / genetics*
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Extremities / embryology*
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Extremities / growth & development*
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Foot Deformities, Congenital / genetics
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Gene Expression Regulation, Developmental
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Genes / genetics
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Hand Deformities, Congenital / genetics
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Humans
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Mice
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Mice, Knockout / genetics