Characterization of FOX-3, an AmpC-type plasmid-mediated beta-lactamase from an Italian isolate of Klebsiella oxytoca

Antimicrob Agents Chemother. 1998 Feb;42(2):464-7. doi: 10.1128/AAC.42.2.464.

Abstract

Klebsiella oxytoca 1731, which showed a wide spectrum of resistance to beta-lactams, including cefoxitin, was isolated in 1994 from a patient in Genoa, Italy. This strain contained a plasmid-mediated AmpC beta-lactamase with a pI of 7.25. Sequencing of the corresponding DNA of K. oxytoca 1731 revealed 96 and 97% identities of the deduced amino acid sequence with FOX-1 and FOX-2, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins*
  • Female
  • Humans
  • Italy
  • Klebsiella / enzymology*
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Plasmids / genetics
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • beta-Lactamases / drug effects
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism
  • beta-Lactams / pharmacology

Substances

  • Bacterial Proteins
  • beta-Lactams
  • FOX-3 protein, Klebsiella oxytoca
  • beta-Lactamases

Associated data

  • GENBANK/Y11068