Kinetic studies of beta-sheet protein folding

Curr Opin Struct Biol. 1998 Feb;8(1):86-92. doi: 10.1016/s0959-440x(98)80014-6.

Abstract

New studies have shown that folding of beta-sheet proteins can occur with and without intermediates, with fast to slow refolding rates and late to very late transition states. These experiments demonstrate that, despite early speculation to the contrary, beta-sheet protein folding does not appear to be fundamentally different from that of helical and mixed alpha, beta proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Kinetics
  • Models, Molecular
  • Peptides / chemistry
  • Protein Conformation
  • Protein Folding*
  • Protein Structure, Secondary*
  • Proteins / chemistry*
  • src Homology Domains

Substances

  • Peptides
  • Proteins