Regional distribution of glutamate receptor mRNA in the monkey hippocampus and temporal cortex: influence of estradiol

Brain Res Mol Brain Res. 1998 Jan;53(1-2):328-32. doi: 10.1016/s0169-328x(97)00282-9.

Abstract

The distribution of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) glutamate receptor subunits was examined in the hippocampus and temporal cortex of adult ovariectomized female rhesus macaques, some of which received estradiol replacement. In situ hybridization revealed a generalized overlap of NR1, GluR1, and GluR2 subunit mRNAs, but no effect due to estradiol treatment. However, regional differences in expression were noted for each subunit.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Estradiol / pharmacology*
  • Estrogen Replacement Therapy
  • Female
  • Gene Expression Regulation / drug effects
  • Hippocampus / drug effects
  • Hippocampus / metabolism*
  • In Situ Hybridization
  • Macaca mulatta
  • Neurons / metabolism*
  • Organ Specificity
  • Ovariectomy
  • RNA, Messenger / metabolism*
  • Receptors, AMPA / biosynthesis*
  • Receptors, N-Methyl-D-Aspartate / biosynthesis*
  • Temporal Lobe / drug effects
  • Temporal Lobe / metabolism*

Substances

  • RNA, Messenger
  • Receptors, AMPA
  • Receptors, N-Methyl-D-Aspartate
  • Estradiol
  • glutamate receptor ionotropic, AMPA 2
  • glutamate receptor ionotropic, AMPA 1