Protective effects of the lipophilic redox conjugate tocopheryl succinyl-ethyl ferulate on HIV replication

FEBS Lett. 1997 Nov 24;418(1-2):15-8. doi: 10.1016/s0014-5793(97)01335-5.

Abstract

Previously, we demonstrated that ferulate ethyl and tocopherol reduced HIV replication. In this study, we investigate whether the conjugation of both compounds (O-tocopheryl succinyl O-ethyl ferulate) can increase HIV inhibition. We show here for the first time that O-tocopheryl succinyl O-ethyl ferulate inhibits 80% of HIV replication (HIV-1 acute infection and HIV transmission), inhibits cell lipoperoxidation and prevents cellular glutathione consumption. Compared to ferulate ethyl and tocopheryl succinyl, O-tocopheryl succinyl O-ethyl ferulate inhibits more HIV replication. This may be due in part to the great increase in the lipophilicity of this compound.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Caffeic Acids / pharmacology
  • Cell Line
  • Cells, Cultured
  • Coumaric Acids / pharmacology*
  • Glutathione / metabolism
  • HIV Core Protein p24 / analysis
  • HIV-1 / drug effects
  • HIV-1 / physiology*
  • Humans
  • Lipid Peroxidation / drug effects*
  • Macrophages / drug effects
  • Macrophages / physiology*
  • Macrophages / virology*
  • Monocytes / cytology
  • Virus Replication / drug effects*
  • Vitamin A / analogs & derivatives*
  • Vitamin A / pharmacology
  • Vitamin E / pharmacology

Substances

  • Caffeic Acids
  • Coumaric Acids
  • HIV Core Protein p24
  • O-tocopherylsuccinyl O-ethyl ferulate conjugate
  • Vitamin A
  • Vitamin E
  • ethyl ferulate
  • Glutathione