Reproducible induction of "atypical" torsades de pointes by programmed electrical stimulation: a novel form of sotalol-induced proarrhythmia?

J Cardiovasc Electrophysiol. 1997 Sep;8(9):1055-61. doi: 10.1111/j.1540-8167.1997.tb00629.x.

Abstract

We present a patient with sotalol-induced polymorphic ventricular tachycardia that was seen only with programmed ventricular stimulation. Electrophysiologic studies performed prior to initiation of sotalol therapy revealed inducible monomorphic ventricular tachycardia. Possible underlying electrophysiologic mechanisms are discussed.

Publication types

  • Case Reports

MeSH terms

  • Anti-Arrhythmia Agents / adverse effects*
  • Anti-Arrhythmia Agents / therapeutic use
  • Cardiac Pacing, Artificial
  • Electric Stimulation
  • Electrocardiography
  • Humans
  • Male
  • Middle Aged
  • Sotalol / adverse effects*
  • Sotalol / therapeutic use
  • Tachycardia, Ventricular / chemically induced
  • Tachycardia, Ventricular / physiopathology
  • Torsades de Pointes / chemically induced
  • Torsades de Pointes / physiopathology*

Substances

  • Anti-Arrhythmia Agents
  • Sotalol