A translocation between 3q21 and 12q24 in a patient with minimally differentiated acute myeloid leukemia (AML-M0)

N Yamagata; C Shimazaki; T Kikuta; H Hirai; T Sumikuma; Y Sudo; E Ashihara; H Goto; T Inaba; N Fujita; M Nakagawa

doi:10.1016/s0165-4608(96)00339-1

A translocation between 3q21 and 12q24 in a patient with minimally differentiated acute myeloid leukemia (AML-M0)

Cancer Genet Cytogenet. 1997 Sep;97(2):90-3. doi: 10.1016/s0165-4608(96)00339-1.

Authors

N Yamagata¹, C Shimazaki, T Kikuta, H Hirai, T Sumikuma, Y Sudo, E Ashihara, H Goto, T Inaba, N Fujita, M Nakagawa

Affiliation

¹ Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.

PMID: 9283587
DOI: 10.1016/s0165-4608(96)00339-1

Abstract

Only a small number of reports have described the cytogenetic analysis of minimally differentiated acute myeloid leukemia (AML, M0). We performed a cytogenetic analysis on a patient with AML (M0) with a normal platelet count. It revealed a chromosomal translocation between chromosome bands 3q21 and 12q24. 3q. Abnormalities in AML are known to be associated with normal or elevated platelet counts. 3q21 and 12q24 are common translocation sites in AML patients, but this is the first report of translocation t(3;12)(q21;q24) in an AML patient.

Publication types

Case Reports

MeSH terms

Cell Differentiation
Chromosome Aberrations*
Chromosome Banding
Chromosome Disorders
Chromosome Mapping
Chromosomes, Human, Pair 12*
Chromosomes, Human, Pair 3*
Humans
Leukemia, Myeloid / genetics*
Leukemia, Myeloid / pathology
Male
Middle Aged
Translocation, Genetic