Synthesis and biological properties of some 2H-1-benzopyrano[7,8-b][1,4]benzodioxin-2-ones

Farmaco. 1997 Jan;52(1):7-12.

Abstract

The synthesis of 2H-benzopyrano[7,8-b][1,4]tetrahydrobenzodioxin-2-ones and 2H-benzopyrano [7,8-b][1,4]benzodioxin-2-ones is reported. This class of compounds, prepared with the aim of obtaining new monofunctional photosensitizing drug, appears to be ineffective upon UVA irradiation but shows a moderate but significant activity in the dark.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Benzopyrans / chemical synthesis*
  • Benzopyrans / pharmacology
  • Carcinoma, Ehrlich Tumor / drug therapy
  • DNA, Neoplasm / biosynthesis
  • Dioxins / chemical synthesis*
  • Dioxins / pharmacology
  • HeLa Cells
  • Humans
  • Photosensitizing Agents / chemical synthesis*
  • Photosensitizing Agents / pharmacology
  • T-Phages / drug effects
  • Tumor Cells, Cultured
  • Ultraviolet Rays

Substances

  • Antineoplastic Agents
  • Benzopyrans
  • DNA, Neoplasm
  • Dioxins
  • Photosensitizing Agents