MDMA and d-amphetamine produce comparable effects in pigeons performing under a multiple fixed-ratio interresponse-time-greater-than-t schedule of food delivery

Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):173-7. doi: 10.1016/s0091-3057(96)00302-4.

Abstract

The purpose of this study was to gain further information about the behavioral effects of (+/-) 3.4-methylenedioxymethamphetamine (MDMA) on schedule-controlled responding. MDMA (0.32, 0.56, 1.0, 3.2, 5.6, and 10 mg/kg) and d-amphetamine (0.32, 0.56, 1.0, 3.2, 5.6, and 10 mg/kg) were administered to pigeons performing under a multiple fixed-ratio 30 (FR 30) interresponse-time-greater-than-15-s (IRT > 15-s) schedule of food delivery. In general, both drugs had no significant effect on response rates under the IRT > 15-s component at doses that decreased rates under the FR component. Results of the present experiment indicate that under some conditions MDMA and d-amphetamine produce similar, and rate-dependent, effects.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Central Nervous System Stimulants / pharmacology*
  • Columbidae
  • Conditioning, Operant / drug effects*
  • Dextroamphetamine / pharmacology*
  • Drug Evaluation, Preclinical
  • Food
  • Hallucinogens / pharmacology*
  • N-Methyl-3,4-methylenedioxyamphetamine / pharmacology*
  • Reaction Time / drug effects
  • Reinforcement Schedule*

Substances

  • Central Nervous System Stimulants
  • Hallucinogens
  • N-Methyl-3,4-methylenedioxyamphetamine
  • Dextroamphetamine