Giant hemangioma of infancy is a rare and extensive variant of the hemangiomas, that occurs in newborns and infants and is often complicated by life-threatening events. We describe herein an unusual case of a giant hemangioma in a female infant. At the age of 45 days she was admitted to the hospital because of increasing respiratory distress and distented abdomen. The response to supportive therapy was poor and the infant died from cardiac arrest on its 75th day of life. Autopsy revealed a giant tumor occupying extensive areas of the thoracic and abdominal cavity. The histologic diagnosis was compatible with a giant capillary hemangioma. A review of the literature was also attempted.