Borna disease virus antibodies and the deficit syndrome of schizophrenia

R W Waltrip 2nd; R W Buchanan; W T Carpenter Jr; B Kirkpatrick; A Summerfelt; A Breier; S A Rubin; K M Carbone

doi:10.1016/s0920-9964(96)00114-4

Borna disease virus antibodies and the deficit syndrome of schizophrenia

Schizophr Res. 1997 Feb 28;23(3):253-7. doi: 10.1016/s0920-9964(96)00114-4.

Authors

R W Waltrip 2nd¹, R W Buchanan, W T Carpenter Jr, B Kirkpatrick, A Summerfelt, A Breier, S A Rubin, K M Carbone

Affiliation

¹ Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland at Baltimore, Catonsville 21228, USA.

PMID: 9075304
DOI: 10.1016/s0920-9964(96)00114-4

Abstract

We detected anti-Borna disease virus (BDV) antibodies at a 14.4% rate in patients with schizophrenia. The hypothesis of a higher rate of BDV seropositivity in deficit syndrome was borne out in a subset of 64 patients categorized according to the Schedule for the Deficit Syndrome with 5/15 seropositive deficit and 4/49 seropositive nondeficit (p < 0.05). This suggests that the antibodies and possibly a BDV-like virus are pathogenetically linked to this form of schizophrenia.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adult
Affective Symptoms / virology*
Borna disease virus / immunology*
Case-Control Studies
Chi-Square Distribution
Cognition Disorders / virology*
Cohort Studies
Female
Humans
Male
Schizophrenia / classification
Schizophrenia / virology*
Syndrome

Grants and funding

etc