Successful treatment of an infection depends first on prompt diagnosis. Management of postoperative wound infections after spinal fusion with instrumentation often presents therapeutic difficulties. This study reviews a total of 28 wound infections. An infection rate of early infection with 3.6% and late infection with 1.9% was noted. The treatment of wound infection depends on the appearance of infection. In early wound infection, it is not always necessary to remove the instrumentation, if a successful suction-irrigation system was inserted. In late wound infection, we removed the hardware in all cases. No evidence of pyogenic infection was presented. Additionally, intravenous antibiotics were used after the antibiogram.