Increasing prevalence and severity of allergic reactions to natural latex rubber have prompted a reevaluation of certain routine practices. Many common health care and household devices can cause allergic reactions, ranging from mild rash to fatal anaphylactic shock, in latex-sensitive persons. Research suggests that populations at risk can be identified, and successful prevention modalities can be developed on the basis of an understanding of the routes of exposure. Several unresolved issues and areas of confusion remain, however, regarding design of latex-safe clinical practice. This article updates nurses on current research and clinical practice related to latex allergies.