Fifteen patients were treated with the expanded thin skin flaps with the large area defects of soft tissue resulting from scar, pigmented nevus, hemangioma, chronic ulcer and neurofibroma. The operative procedure includes tissue expansion and defatted flap transplantation. All flaps that preserved only a thickness of 3 mm adipose tissue or superficial fascia beneath the subdermal vascular network survived with the primary healing of 12 cases and the delay healing of 3 cases in the maximal ratio of length to width 4.3:1. The details of clinical experience and primary experiment were presented.