[Diagnosis and targeting therapy of colorectal cancer using antibody]

Gan To Kagaku Ryoho. 1996 Apr;23(5):549-53.
[Article in Japanese]

Abstract

Application of monoclonal antibody for diagnosis and therapy of colorectal cancer was reviewed. The history and present status of radioimmunoimaging of cancer were presented. Immuno-guided surgery using radiolabeled antibody and hand-aided detector during surgery is a promising approach for complete excision of cancerous region. Also, a new antibody labeling method using a micro-magnet instead of radioisotopes may lead to a new era in immunodiagnosis of cancer. Finally, immunotargeting chemotherapy using antibody-anticancer drug conjugates was reviewed. A new type of immunoconjugate composed of human/mouse chimeric antibody and Neocarzinostatin seems to be one of the most promising drug formulas for immunotargeting chemotherapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antibiotics, Antineoplastic / therapeutic use
  • Antibodies, Monoclonal* / therapeutic use
  • Colorectal Neoplasms / diagnosis
  • Colorectal Neoplasms / diagnostic imaging
  • Colorectal Neoplasms / therapy
  • Humans
  • Immunotoxins / therapeutic use*
  • Radioimmunodetection
  • Zinostatin / therapeutic use

Substances

  • Antibiotics, Antineoplastic
  • Antibodies, Monoclonal
  • Immunotoxins
  • Zinostatin