Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q

S D Detera-Wadleigh; J A Badner; L R Goldin; W H Berrettini; A R Sanders; D Y Rollins; G Turner; T Moses; H Haerian; D Muniec; J I Nurnberger Jr; E S Gershon

Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q

Am J Hum Genet. 1996 Jun;58(6):1279-85.

Authors

S D Detera-Wadleigh¹, J A Badner, L R Goldin, W H Berrettini, A R Sanders, D Y Rollins, G Turner, T Moses, H Haerian, D Muniec, J I Nurnberger Jr, E S Gershon

Affiliation

¹ Clinical Neurogenetics Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA. sevilla@helix.nih.gov

PMID: 8651306
PMCID: PMC1915054

Abstract

In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess allele sharing (nominal P values <.01) under two affection-status models, ASM I (bipolars and schizoaffectives) and ASM II (ASM I plus recurrent unipolars). In addition, under ASM I, the proximal interval spanned by D21S1436 and D21S65 showed locus trios with excess allele sharing (nominal P values of .03-.0003). These findings support prior evidence that a susceptibility locus for bipolar disorder is on 21q.

MeSH terms

Bipolar Disorder / epidemiology
Bipolar Disorder / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 21*
Disease Susceptibility
Female
Genetic Linkage
Genetic Markers
Genotype
Humans
Lod Score
Male
Nuclear Family
Pedigree
Polymerase Chain Reaction
Repetitive Sequences, Nucleic Acid
Risk Assessment

Substances

Genetic Markers