A 3 3/12-year-old female child with abdominal distention, new onset pain, and tenderness is described. The child underwent surgical resection of a multilocular cyst of the right lobe of the liver. We reviewed the autopsy and surgical files of Children's Hospital for the past 63 years to identify other congenital cysts of the liver. We found 30 additional cases including 4 multilocular cysts. The origin of these cysts, a review of the literature, and a discussion of diagnostic parameters for the identification of such cysts in context with other hepatobiliary cystic lesions are presented.