Friedreich's ataxia with retained tendon reflexes: molecular genetics, clinical neurophysiology, and magnetic resonance imaging

Neurology. 1996 Jan;46(1):118-21. doi: 10.1212/wnl.46.1.118.

Abstract

Lower limb areflexia is generally regarded as an essential criterion for the diagnosis of Friedreich's ataxia (FRDA). We describe a family with a recessive form of early-onset ataxia in which one member had a phenotype typical of FRDA whereas another, with retained tendon reflexes in the lower limbs, did not have electrophysiologic evidence of the usual severe afferent axonal neuropathy of FRDA. In contrast, somatosensory evoked potentials, eye-movement recordings, and MRI of the head and cervical cord provided results highly suggestive of FRDA in both patients. We performed genetic linkage analysis in this family, using markers tightly linked to the FRDA locus on chromosome 9. Inheritance of identical paternal and maternal genotypes by the affected members, but not by their unaffected siblings, provided supporting evidence that this disorder may result from mutation within the FRDA gene or is tightly linked to the investigated loci on chromosome 9.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / pathology
  • Female
  • Friedreich Ataxia* / genetics
  • Friedreich Ataxia* / pathology
  • Friedreich Ataxia* / physiopathology
  • Genetic Linkage
  • Humans
  • Magnetic Resonance Imaging
  • Mutation
  • Pedigree