Linkage analysis of fifty-seven microsatellite loci to bipolar disorder

Neuropsychopharmacology. 1993 Aug;9(1):31-40. doi: 10.1038/npp.1993.40.

Abstract

The authors' goal was to screen for genetic linkage with highly informative deoxyribonucleic acid (DNA) microsatellite markers on a series of moderately sized North American bipolar disorder (BP) pedigrees. These BP pedigrees were genotyped with 57 short tandem-repeat polymorphic systems (microsatellites) that were enzymatically amplified from genomic DNA. We did not find significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bipolar Disorder / genetics*
  • Chromosomes, Human / ultrastructure
  • DNA, Satellite / genetics*
  • Electrophoresis
  • Gene Amplification
  • Genetic Linkage / genetics*
  • Genetic Markers / genetics
  • Genotype
  • Humans
  • Kinetics
  • Models, Genetic
  • Polymorphism, Genetic

Substances

  • DNA, Satellite
  • Genetic Markers