Cardiovascular protection by oestrogen--a calcium antagonist effect?

P Collins; G M Rosano; C Jiang; D Lindsay; P M Sarrel; P A Poole-Wilson

doi:10.1016/0140-6736(93)91158-i

Cardiovascular protection by oestrogen--a calcium antagonist effect?

Lancet. 1993 May 15;341(8855):1264-5. doi: 10.1016/0140-6736(93)91158-i.

Authors

P Collins¹, G M Rosano, C Jiang, D Lindsay, P M Sarrel, P A Poole-Wilson

Affiliation

¹ Department of Cardiac Medicine, National Heart and Lung Institute, London, UK.

PMID: 8098404
DOI: 10.1016/0140-6736(93)91158-i

Abstract

During their premenopausal years, women have a lower risk than men of getting cardiovascular disease. This protection continues after the menopause if women receive oestrogen replacement. Based on new experimental evidence we propose that some of the cardiovascular benefits of oestrogen replacement therapy may be due to a long-term calcium antagonist effect of oestrogen.

MeSH terms

Animals
Arteriosclerosis / prevention & control*
Calcium / antagonists & inhibitors*
Calcium Channel Blockers / pharmacology
Cardiovascular System / drug effects*
Coronary Disease / prevention & control*
Coronary Vessels / drug effects
Endothelium, Vascular / drug effects
Estrogen Replacement Therapy
Estrogens / pharmacology
Estrogens / therapeutic use*
Female
Hemodynamics / drug effects
Humans

Substances

Calcium Channel Blockers
Estrogens
Calcium