Myocardial salvage by chimyl alcohol: possible role of peroxisomal dysfunction in reperfusion injury

N Maulik; A Tosaki; R M Engelman; G A Cordis; D K Das

Myocardial salvage by chimyl alcohol: possible role of peroxisomal dysfunction in reperfusion injury

Ann N Y Acad Sci. 1994 Jun 17:723:380-4.

Authors

N Maulik¹, A Tosaki, R M Engelman, G A Cordis, D K Das

Affiliation

¹ Department of Surgery, University of Connecticut School of Medicine, Farmington 06030.

PMID: 8030890

Abstract

The results of this study suggest that reperfusion of ischemic myocardium may lead to the peroxisomal disorder both functionally and biochemically. An alkyl glycerol such as chimyl alcohol can protect the ischemic heart from the reperfusion injury probably by enhancing the plasmalogen synthesis.

MeSH terms

Animals
Catalase / metabolism
Glyceryl Ethers / pharmacology*
Microbodies / physiology*
Myocardial Reperfusion Injury / physiopathology
Myocardial Reperfusion Injury / prevention & control*
Plasmalogens / metabolism
Rats
Rats, Sprague-Dawley

Substances

Glyceryl Ethers
Plasmalogens
Catalase
chimyl alcohol