Acquired factor VIII inhibitor associated with chronic interferon-alpha therapy in a patient with haemophilia A

Br J Haematol. 1994 Jun;87(2):434-6. doi: 10.1111/j.1365-2141.1994.tb04941.x.

Abstract

Both the development of factor VIII inhibitors and infection by hepatitis C virus are serious complications of haemophilia A. We describe the first reported case of the subsequent development of a factor VIII inhibitor in a patient with haemophilia A after treatment with interferon-alpha for chronic active hepatitis C.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Factor VIII / antagonists & inhibitors*
  • Hemophilia A / blood*
  • Hemophilia A / complications
  • Hepatitis C / complications
  • Hepatitis C / therapy*
  • Hepatitis, Chronic / complications
  • Hepatitis, Chronic / therapy*
  • Humans
  • Interferon-alpha / adverse effects*
  • Interferon-alpha / therapeutic use
  • Male

Substances

  • Interferon-alpha
  • Factor VIII