Abstract
Among vascular cell adhesion molecules, platelet-endothelial cell adhesion molecule (PECAM-1/CD31) has the distinctive feature of being expressed on several of the major cell types associated with the vascular compartment. This makes it uniquely positioned to mediate multiple and important cell-cell interactions involving platelets, leukocytes and endothelial cells. Thus, PECAM-1 may represent a potential target for new therapeutic agents directed at a variety of pathological states.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Alternative Splicing
-
Animals
-
Antibodies, Monoclonal / immunology
-
Antigens, Differentiation, Myelomonocytic / biosynthesis
-
Antigens, Differentiation, Myelomonocytic / chemistry
-
Antigens, Differentiation, Myelomonocytic / genetics
-
Antigens, Differentiation, Myelomonocytic / immunology
-
Antigens, Differentiation, Myelomonocytic / physiology*
-
Cell Adhesion / immunology
-
Cell Adhesion Molecules / biosynthesis
-
Cell Adhesion Molecules / chemistry
-
Cell Adhesion Molecules / genetics
-
Cell Adhesion Molecules / immunology
-
Cell Adhesion Molecules / physiology*
-
Fluorescent Antibody Technique
-
Humans
-
Platelet Endothelial Cell Adhesion Molecule-1
Substances
-
Antibodies, Monoclonal
-
Antigens, Differentiation, Myelomonocytic
-
Cell Adhesion Molecules
-
Platelet Endothelial Cell Adhesion Molecule-1