One hundred eight high-lean-growth gilts (34.4 kg BW) were used to determine the dietary lysine requirement to maximize growth, carcass characteristics, and protein accretion from 34 to 72.5 kg BW. The experiment was a randomized complete block design; initial BW served as the blocking factor. Six dietary treatments were included, ranging from .54 to 1.04% (.10% increments) digestible lysine (.69 to 1.25% total lysine). Pigs were housed in pens of three, with six replicate pens per treatment. Pig weights and feed consumption were collected weekly to calculate ADG, ADFI, and gain:feed (G/F). Initially, five pigs were slaughtered to determine baseline carcass composition. When the mean weight for pigs in a pen reached 55 and 72.5 kg, one pig per pen was randomly selected and slaughtered for carcass measurements. The right side of each carcass was ground twice and sampled to determine carcass composition and tissue accretion rates. Average daily gain was increased by dietary lysine from 34 to 55 kg (linear, P < .01), from 55 to 72.5 kg (linear, P < .10), and from 34 to 72.5 kg (linear, P < .01). Although ADFI from 34 to 55 and from 55 to 72.5 kg was not influenced by dietary lysine, ADFI for the entire experiment tended to decrease (quadratic, P < .10) as digestible lysine increased. Increased dietary lysine resulted in improved G/F from 34 to 55 kg (linear, P < .01) and from 55 to 72.5 and 34 to 72.5 kg (quadratic, P < .01). Average backfat thickness was not influenced by dietary lysine at 55 kg but decreased (linear, P < .05) as dietary lysine increased at 72.5 kg. At 55 kg, longissimus muscle area was larger (linear, P < .05) for gilts fed increased digestible lysine. However, longissimus muscle area was similar for all treatments at 72.5 kg. Gilts fed increased digestible lysine had greater CP accretion from 34 to 55 kg (linear, P < .01), 55 to 72.5 kg (linear, P < .05; quadratic, P < .10), and from 34 to 72.5 kg (quadratic, P < .05). Based on the feed intake observed in this study, the high-lean-growth gilt requires at least 22 g/d total lysine intake from 34 to 72.5 kg to maximize CP accretion.