This report presents the arteries of the mesencephalo-diencephalic region and their different role in the supply to the cerebral structures. Among them, the authors distinguish the subependymal and transmesencephalic arteries to which they pay a special attention since these vessels present a specific angiographic aspect. The importance of their differentiation is emphasized. The authors discuss the management of subependymal and (trans)mesencephalic arteries during endovascular neuro-intervention illustrative cases.