Well differentiated astrocytoma occurring nine years after radiation therapy for medulloblastoma

Clin Neuropathol. 1994 Sep-Oct;13(5):281-5.

Abstract

Conventional treatment for medulloblastoma includes surgical resection followed by craniospinal irradiation, with the potential risk of subsequent radiotherapy-induced secondary neoplasms. We report a 23-year-old woman previously irradiated nine years earlier for a cerebellar medulloblastoma who developed a new enhancing lesion in the primary radiation field four weeks following completion of high dose chemotherapy with bone marrow transplantation for recurrent disease. Resection of this lesion revealed a low grade glioma with no evidence of recurrent medulloblastoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Astrocytoma / pathology*
  • Cerebellar Neoplasms / drug therapy
  • Cerebellar Neoplasms / pathology
  • Cerebellar Neoplasms / radiotherapy*
  • Cerebellum / drug effects
  • Cerebellum / pathology
  • Cerebellum / radiation effects
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Cranial Irradiation*
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging
  • Medulloblastoma / drug therapy
  • Medulloblastoma / pathology
  • Medulloblastoma / radiotherapy*
  • Neoplasm Recurrence, Local / drug therapy
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / radiotherapy
  • Neoplasms, Multiple Primary / pathology*
  • Neoplasms, Radiation-Induced / pathology*
  • Radiotherapy, Adjuvant