The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event

J W Janssen; S A Ridge; P Papadopoulos; F Cotter; W D Ludwig; C Fonatsch; H Rieder; W Ostertag; C R Bartram; L M Wiedemann

doi:10.1111/j.1365-2141.1995.tb03407.x

The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event

Br J Haematol. 1995 May;90(1):222-4. doi: 10.1111/j.1365-2141.1995.tb03407.x.

Authors

J W Janssen¹, S A Ridge, P Papadopoulos, F Cotter, W D Ludwig, C Fonatsch, H Rieder, W Ostertag, C R Bartram, L M Wiedemann

Affiliation

¹ Department of Paediatrics II, University of Ulm, Germany.

PMID: 7786792
DOI: 10.1111/j.1365-2141.1995.tb03407.x

Abstract

We have recently identified a common ALL patient which harboured a chromosomal fusion between the TEL gene on chromosome 12 and the ABL gene on chromosome 9. We designed an RT-PCR assay to screen 186 adult ALL and 30 childhood ALL patients for this novel translocation. We were unable to identify any additional cases with a TEL/ABL fusion product.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Base Sequence
Child
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 9
Cloning, Molecular*
DNA-Binding Proteins / genetics*
ETS Translocation Variant 6 Protein
Genes, abl*
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Proto-Oncogene Proteins c-ets
Repressor Proteins*
Transcription Factors / genetics*

Substances

DNA-Binding Proteins
Proto-Oncogene Proteins c-ets
Repressor Proteins
Transcription Factors