Studies on the antitumor 2,6-piperazinediones: synthesis of 2,3-diacetoxy-4-carbomethoxy-(3',5'-dioxo-N4' substituted piperazinyl methyl) benzene

Q Li; H W Shao; H L Jiang; Y Y Xie

Studies on the antitumor 2,6-piperazinediones: synthesis of 2,3-diacetoxy-4-carbomethoxy-(3',5'-dioxo-N4' substituted piperazinyl methyl) benzene

Pharmazie. 1995 Jul;50(7):447-9.

Authors

Q Li¹, H W Shao, H L Jiang, Y Y Xie

Affiliation

¹ Department of Synthetic Chemistry, Shanghai Institute of Materia Medica, Academia Sinica, P.R. of China.

PMID: 7675884

Abstract

The title compounds having the structure of 2,3-diacetoxy-4-carbomethoxy-(3',5'-dioxo-N4'-substituted piperazinyl methyl) benzene were synthesized from 2-hydroxy-3-methoxybenzaldehyde in eight steps. Compound 9h showed a potent inhibitory effect against P388 leukemia cells in vitro.

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Benzene Derivatives / chemical synthesis*
Benzene Derivatives / pharmacology
Chemical Phenomena
Chemistry, Physical
Drug Screening Assays, Antitumor
Humans
Leukemia P388 / drug therapy
Piperazines / chemical synthesis*
Piperazines / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Benzene Derivatives
Piperazines