Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease

Neurosci Lett. 1995 Mar 31;188(3):202-4. doi: 10.1016/0304-3940(95)11422-s.

Abstract

The possibility of a genetic association between late onset, familial Alzheimer's disease and alleles at the apolipoprotein B and AI/CIII loci have been examined. In contrast to the genetic association with the apolipoprotein E locus, no evidence for genetic associations to these loci was found.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Alleles
  • Alzheimer Disease / genetics*
  • Apolipoprotein A-I / genetics*
  • Apolipoproteins B / genetics*
  • Apolipoproteins C / genetics*
  • Apolipoproteins E / genetics*
  • DNA / blood
  • Female
  • Humans
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length

Substances

  • Apolipoprotein A-I
  • Apolipoproteins B
  • Apolipoproteins C
  • Apolipoproteins E
  • DNA