[Multiple cutaneous neoplasms in cyclosporine therapy after kidney transplantation]

Hautarzt. 1995 Sep;46(9):638-42. doi: 10.1007/s001050050311.
[Article in German]

Abstract

We report on a 56-year-old renal allograft recipient receiving cyclosporin A immunosuppression. During this therapy he subsequently developed the following cutaneous neoplasms: squamous cell carcinomas, basal cell carcinomas, Bowen's disease, actinic keratosis, sebaceous hyperplasia, a dysplastic naevus and, finally a nodular malignant melanoma. Adverse effects of the cyclosporin A therapy are discussed, with special reference to dermatologic effects and the implications for patient and doctor.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Bowen's Disease / chemically induced
  • Bowen's Disease / immunology
  • Carcinoma, Basal Cell / chemically induced
  • Carcinoma, Basal Cell / immunology
  • Carcinoma, Squamous Cell / chemically induced
  • Carcinoma, Squamous Cell / immunology
  • Cell Transformation, Neoplastic / chemically induced
  • Cell Transformation, Neoplastic / immunology
  • Cyclosporine / administration & dosage
  • Cyclosporine / adverse effects*
  • Diabetic Nephropathies / immunology
  • Diabetic Nephropathies / surgery*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Dysplastic Nevus Syndrome / chemically induced
  • Dysplastic Nevus Syndrome / immunology
  • Follow-Up Studies
  • Humans
  • Immune Tolerance / drug effects
  • Kidney Transplantation / immunology*
  • Male
  • Melanoma / chemically induced
  • Melanoma / immunology
  • Middle Aged
  • Neoplasms, Multiple Primary / chemically induced*
  • Neoplasms, Multiple Primary / immunology
  • Precancerous Conditions / chemically induced
  • Precancerous Conditions / immunology
  • Skin Neoplasms / chemically induced*
  • Skin Neoplasms / immunology

Substances

  • Cyclosporine