Abstract
We report on a 56-year-old renal allograft recipient receiving cyclosporin A immunosuppression. During this therapy he subsequently developed the following cutaneous neoplasms: squamous cell carcinomas, basal cell carcinomas, Bowen's disease, actinic keratosis, sebaceous hyperplasia, a dysplastic naevus and, finally a nodular malignant melanoma. Adverse effects of the cyclosporin A therapy are discussed, with special reference to dermatologic effects and the implications for patient and doctor.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Bowen's Disease / chemically induced
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Bowen's Disease / immunology
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Carcinoma, Basal Cell / chemically induced
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Carcinoma, Basal Cell / immunology
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Carcinoma, Squamous Cell / chemically induced
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Carcinoma, Squamous Cell / immunology
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Cell Transformation, Neoplastic / chemically induced
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Cell Transformation, Neoplastic / immunology
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Cyclosporine / administration & dosage
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Cyclosporine / adverse effects*
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Diabetic Nephropathies / immunology
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Diabetic Nephropathies / surgery*
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Dysplastic Nevus Syndrome / chemically induced
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Dysplastic Nevus Syndrome / immunology
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Follow-Up Studies
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Humans
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Immune Tolerance / drug effects
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Kidney Transplantation / immunology*
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Male
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Melanoma / chemically induced
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Melanoma / immunology
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Middle Aged
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Neoplasms, Multiple Primary / chemically induced*
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Neoplasms, Multiple Primary / immunology
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Precancerous Conditions / chemically induced
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Precancerous Conditions / immunology
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Skin Neoplasms / chemically induced*
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Skin Neoplasms / immunology