Histamine H1-receptors labeled in vivo: antidepressant and antihistamine interactions

Eur J Pharmacol. 1980 Jun 13;64(2-3):177-81. doi: 10.1016/0014-2999(80)90043-6.

Abstract

3H-Mepyramine labels specific histamine H1-receptors in brains of mice after intravenous injection. The potencies of H1-antihistamines in reducing 3H-mepyramine binding in vivo correspond to their pharmacological activities and show parallels with their affinities for 3H-mepyramine binding sites in isolated brain membranes. Several antidepressants are potent in competing for 3H-mepyramine binding in vivo as well as in vitro.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antidepressive Agents / metabolism*
  • Binding Sites
  • Brain / metabolism
  • Chlorpheniramine / metabolism
  • Drug Interactions
  • Histamine Antagonists / metabolism*
  • In Vitro Techniques
  • Isotope Labeling*
  • Mice
  • Pyrilamine / metabolism
  • Receptors, Histamine / metabolism*
  • Receptors, Histamine H1 / metabolism*
  • Time Factors
  • Tritium

Substances

  • Antidepressive Agents
  • Histamine Antagonists
  • Receptors, Histamine
  • Receptors, Histamine H1
  • Tritium
  • Chlorpheniramine
  • Pyrilamine