Abstract
Administration of estrogen to rats during the period of withdrawal from chronic haloperidol attenuated the characteristic increase in apomorphine-induced stereotypy and the increase in (3H) spiroperidol binding. This apparent ability of estrogen to "down-regulate" brain dopamine receptors could lead to useful pharmacological treatments of tardive dyskinesia and possibly of other hyperdopaminergic states.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Apomorphine / pharmacology
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Drug Administration Schedule
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Estradiol / metabolism*
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Female
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Haloperidol / metabolism
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Humans
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In Vitro Techniques
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Radioligand Assay
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine / metabolism*
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Spiperone / metabolism
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Stereotyped Behavior
Substances
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Receptors, Dopamine
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Estradiol
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Spiperone
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Haloperidol
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Apomorphine