Nucleotide sequences of the human and mouse atrial natriuretic factor genes

Science. 1984 Dec 7;226(4679):1206-9. doi: 10.1126/science.6542248.

Abstract

Mouse and human atrial natriuretic factor (ANF) genes have been cloned and their nucleotide sequences determined. Each ANF gene consists of three coding blocks separated by two intervening sequences. The 5' flanking sequences and those encoding proANF are highly conserved between the two species, while the intervening sequences and 3' untranslated regions are not. The conserved sequences 5' of the gene may play an important role in the regulation of ANF gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Atrial Natriuretic Factor*
  • Base Sequence
  • Cloning, Molecular
  • Gene Expression Regulation
  • Genes
  • Heart Atria / metabolism
  • Humans
  • Mice
  • Natriuretic Agents
  • Protein Precursors / genetics
  • Proteins / genetics*
  • Receptors, Glucocorticoid / metabolism

Substances

  • NPPA protein, human
  • Natriuretic Agents
  • Protein Precursors
  • Proteins
  • Receptors, Glucocorticoid
  • Atrial Natriuretic Factor

Associated data

  • GENBANK/K02043
  • GENBANK/K02781