Prediction of relapse in hyperthyroid Graves' disease

Lancet. 1980 May 24;1(8178):1101-3. doi: 10.1016/s0140-6736(80)91551-2.

Abstract

Within a year of stopping a 6-month course of carbimazole treatment 41 of 65 patients (63%) with hyperthyroid Graves' disease had a recurrence of their hyperthyroidism. By combined analysis of the HLA-DRw3 status and the level of thyrotrophin-receptor antibody at the time of drug withdrawal relapse or remission could be predicted in 62 of the 65 patients.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Autoantibodies / analysis
  • Carbimazole / administration & dosage*
  • Female
  • Graves Disease / drug therapy*
  • Graves Disease / immunology
  • HLA Antigens / analysis
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Receptors, Cell Surface / immunology
  • Recurrence
  • Remission, Spontaneous
  • Thyrotropin / immunology
  • Time Factors

Substances

  • Autoantibodies
  • HLA Antigens
  • Receptors, Cell Surface
  • Carbimazole
  • Thyrotropin