Progressive muscular dystrophy type Duchenne. II. Viscosity and resistence to erythrolytic compounds of erythrocyte membranes

Boll Soc Ital Biol Sper. 1979 Jun 30;55(11):1028-32.

Abstract

The transition temperature of erythrocyte ghosts of normal subjects is about 18-20 degrees C. We have studied the viscosity of erythrocyte ghosts of dystrophic children, showing that the transition shifts to lower temperatures (17-18 degrees C). After treatment with erythrocytic compounds like L-Lyso phosphatidyl-Choline dystrophic erythrocytes hemolize at lower Lysophosphatidyl-Choline concentration and at a greater extents than these of normal and carriers subjects.

MeSH terms

  • Erythrocyte Membrane / analysis*
  • Erythrocytes / analysis*
  • Erythrocytes / drug effects
  • Erythrocytes / metabolism
  • Hemoglobins / metabolism
  • Humans
  • Lysophosphatidylcholines / pharmacology
  • Muscular Dystrophies / blood*
  • Temperature
  • Viscosity

Substances

  • Hemoglobins
  • Lysophosphatidylcholines