[Idiopathic hypercalciuria: effects of acute phosphorus deficiency (author's transl)]

Nouv Presse Med. 1979 Nov 12;8(44):3619-22.
[Article in French]

Abstract

Eleven patients with kidney stone disease and idiopathic hypercalciuria (urinary calcium above 4 mg/kg/j), without phosphorus renal leak and 6 control subjects have been put for 3 days on a diet containing 1 g calcium and 1 phosphorus daily (period A), and then for 4 days on a diet containing 1 g calcium, 450 mg phosphorus and 3 g aluminium hydroxyde daily (period B). During period A, no significant difference in blood calcium, phosphorus and magnesium, not in phosphaturia, rate of phosphorus reabsorption (RPR) and ratio maximum RPR/creatinine clearance was found between the two groups. After 2 days on a low phosphate diet (period B) the blood phosphorus decreased significantly in the hypercalciuric patients but not in the control subjects, thus revealing among the forme a latent abnormality in the retention of phosphates. This abnormality could play an important role in the pathogenesis of hypercalciuria.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Calcium / urine*
  • Calcium Metabolism Disorders / diet therapy
  • Calcium Metabolism Disorders / etiology*
  • Female
  • Humans
  • Kidney / metabolism
  • Kidney Calculi / diet therapy
  • Kidney Calculi / etiology
  • Magnesium / blood
  • Male
  • Phosphates / administration & dosage
  • Phosphorus / deficiency*
  • Phosphorus Metabolism Disorders / complications*

Substances

  • Phosphates
  • Phosphorus
  • Magnesium
  • Calcium