Abstract
The uptake of neutral red into the renin-containing juxtaglomerular granules does not inhibit the release of renin either in basal or in stimulated states of renin secretion. The vasodilating effect of neutral red may be due to a nonspecific binding to noradrenaline-receptors in the vascular smooth muscle cells.
MeSH terms
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Angiotensin II / blood
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Animals
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Blood Pressure / drug effects
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Juxtaglomerular Apparatus / drug effects
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Juxtaglomerular Apparatus / enzymology*
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Male
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Neutral Red / pharmacology*
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Norepinephrine / pharmacology
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Phenazines / pharmacology*
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Rats
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Renin / metabolism*
Substances
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Phenazines
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Angiotensin II
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Neutral Red
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Renin
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Norepinephrine