CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ

Juan Tang; Donglin Yu; Jiaojiao Song; Junfei Li; Yijuan Zhang; Xiangrui Ma; Wenlong Wang

doi:10.3389/fonc.2024.1498139

CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ

Front Oncol. 2024 Dec 3:14:1498139. doi: 10.3389/fonc.2024.1498139. eCollection 2024.

Authors

Juan Tang^#^{1

2}, Donglin Yu^#^{1

2}, Jiaojiao Song³, Junfei Li^{1

2}, Yijuan Zhang⁴, Xiangrui Ma^{1

2}, Wenlong Wang^{1

2}

Affiliations

¹ Department of Oral and Maxillofacial Surgery, Binzhou Medical University Hospital, Binzhou, China.
² School of Stomatology, Binzhou Medical University, Yantai, China.
³ Plantation Center, Weihai Stomatological Hospital, Weihai, China.
⁴ Department of Anesthesiology, Binzhou Medical University Hospital, Binzhou, China.

^# Contributed equally.

Abstract

Introduction: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3ζ) is central to various signalling pathways and is pivotal in tumour progression.

Methods: Cancerous and corresponding non-cancerous tissue samples were collected from five patients diagnosed with HNSCC. circRNA and mRNA expression profiles were analyzed using high-throughput sequencing techniques. Potential circRNA-microRNA (miRNA)-mRNA interactions were predicted using bioinformatics tools.

Results: The study found that CircRNA_036186 regulates the expression of 14-3-3ζ in HNSCC through miR-193b-5p.

Discussion: These findings suggest that CircRNA_036186 has the potential to be a biomarker and therapeutic target for HNSCC and provide some theoretical basis for further research on the role of circRNA in HNSCC.

Keywords: 14-3-3ζ; CircRNA; MiRNA; bioinformatics analysis; head and neck squamous cell carcinoma; high throughput sequencing technology.