Novel insights into non-coding RNAs and their role in hydrocephalus

Zhiyue Cui; Jian He; An Li; Junqiang Wang; Yijian Yang; Kaiyue Wang; Zhikun Liu; Qian Ouyang; Zhangjie Su; Pingsheng Hu; Gelei Xiao

doi:10.4103/NRR.NRR-D-24-00963

Novel insights into non-coding RNAs and their role in hydrocephalus

Neural Regen Res. 2024 Dec 16. doi: 10.4103/NRR.NRR-D-24-00963. Online ahead of print.

Authors

Zhiyue Cui^{1

2

3

4}, Jian He⁵, An Li^{2

3

4}, Junqiang Wang^{2

3

4}, Yijian Yang^{2

3

4}, Kaiyue Wang^{2

3

4}, Zhikun Liu^{2

3

4}, Qian Ouyang^{2

3

4

6}, Zhangjie Su⁷, Pingsheng Hu¹, Gelei Xiao^{2

3

4}

Affiliations

¹ Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan Province, China.
² Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
³ Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
⁴ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
⁵ Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
⁶ Department of Neurosurgery, Zhuzhou Hospital, Central South University Xiangya School of Medicine, Zhuzhou, Hunan Province, China.
⁷ Department of Neurosurgery, Addenbrooke 's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.

PMID: 39688559
DOI: 10.4103/NRR.NRR-D-24-00963

Abstract

A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation. This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiological mechanisms underlying hydrocephalus, one of the most common neurological conditions worldwide. In this review, we first outline the basic concepts and incidence of hydrocephalus along with the limitations of existing treatments for this condition. Then, we outline the definition, classification, and biological role of non-coding RNAs. Subsequently, we analyze the roles of non-coding RNAs in the formation of hydrocephalus in detail. Specifically, we have focused on the potential significance of non-coding RNAs in the pathophysiology of hydrocephalus, including glymphatic pathways, neuroinflammatory processes, and neurological dysplasia, on the basis of the existing evidence. Lastly, we review the potential of non-coding RNAs as biomarkers of hydrocephalus and for the creation of innovative treatments.