Elevated Serum Direct Bilirubin and Smoking Status Are Prognostic Factors for EGFR-Mutated Non-Small Cell Lung Cancer Patients Receiving Tyrosine Kinase Inhibitor Therapy

Cancers (Basel). 2024 Nov 27;16(23):3982. doi: 10.3390/cancers16233982.

Jingyuan Zhang^{1

2}, Yinwang Zhang³, Yuqiong Lei¹, Qi Zheng¹, Xiaohua Gu¹, Zeyu Liu¹, Yongle Xu¹, Cheng Zhong¹, Shan Shan¹, Tao Ren^{1

4}

¹ Department of Respiratory Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233, China.
² School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China.
³ Department of Orthopedics, Shanghai Xuhui Central Hospital, 966 Huaihai Road, Shanghai 200031, China.
⁴ Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Road, Shanghai 200233, China.

Abstract

Lung cancer is one of the leading causes of cancer-related death worldwide [...].

Keywords: EGFR-mutated non-small cell lung cancer; direct bilirubin; predictor; smoking; tyrosine kinase inhibitors.