Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis

Abstract

The present research uncovers the shared genetic underpinnings of fairness norm adaptation capability, its neural correlates, and long-term mental health outcomes. One hundred and eighty-six twins are recruited and played as responders in the Ultimatum Game (UG) while undergoing fMRI scanning in their early adulthood (Study-1) and are measured on depressive symptoms eight years later (Study-2). With computational modeling, the process of norm adaptation is differentiated from that of fairness valuation in UG. The two processes both have moderate levels of heritability. The anterior insula has a significant phenotypic correlation, whereas the Supplementary Motor Area/Medial Frontal Gyrus (SMA/mSFG) shows both a significant phenotypic correlation and a shared genetic influence with the learning rate, an index for norm adaptation. The dopaminergic DRD2 polymorphisms correlate with both the learning rate and the SMA/mSFG encoding of prediction error, constituting of their common genetic basis. Regional gene expression analysis reveals the high expression of dopamine-related genes in the SMA/mSFG. Moreover, the learning rate can predict depressive symptom severity eight years later, with the DRD2 polymorphisms constituting their shared genetic basis. This suggests that heritability is a non-negligible driving force behind norm adaptation, which facilitates the learning of social norms in changing environments and preserves long-term mental health.

Keywords: anterior insula; fairness norm adaptation; genetics; prediction error encoding; supplementary motor area; twin studies.