Portulaca Oleracea L. as a Potential Therapeutic Drug Intervention in Ulcerative Colitis: Mechanisms of Action and Clinical Studies

Drug Des Devel Ther. 2024 Dec 11:18:5931-5946. doi: 10.2147/DDDT.S486407. eCollection 2024.

Abstract

Portulaca oleracea L. (POL) has a long history of medicinal use worldwide, and numerous clinical and experimental studies demonstrated the therapeutic effects of POL and its active ingredients in the treatment of Ulcerative colitis (UC). In this review, we summarized the underlying mechanisms and roles of POL in UC treatment based on experimental and clinical studies. The research articles cited in this study were obtained by employing specific keywords, such as "purslane", "IBD", "UC", "inflammation", "gut microbiota", and "intestinal barrier", in PubMed, Web of Science, Google Scholar, and China National Knowledge Infrastructure databases. Clinical studies found that both POL monotherapy and POL traditional Chinese medicine compound are effective in treating UC. Meanwhile, experimental studies found that POL intervenes in UC by regulating intestinal flora, repairing mucosal barrier, and regulating immune response. Increasing evidence suggests the therapeutic potential of POL in UC treatment.

Keywords: Portulaca oleracea L.; gut microbiota; immunoregulation; intestinal barrier; ulcerative colitis.

Publication types

  • Review

MeSH terms

  • Animals
  • Colitis, Ulcerative* / drug therapy
  • Gastrointestinal Microbiome / drug effects
  • Humans
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Portulaca* / chemistry

Substances

  • Plant Extracts

Grants and funding

This study was funded by the grants from the National Natural Science Foundation of China, No. 81873253; the Shanghai Natural Science Foundation, No. 22ZR1458800; the scientific research Project Plan of Shanghai Municipal Health Commission, No. 202240385; the XingLin Scholar Program of Shanghai University of Traditional Chinese Medicine, No. [2020]23; and the Science and Technology Innovation Cultivation Program of LongHua, No.YD202220.