Leveraging spatial multiomics to unravel tissue architecture in embryo development

Fuqing Jiang; Haoxian Wang; Zhuxia Li; Guizhong Cui; Guangdun Peng

doi:10.1016/j.tig.2024.11.007

Leveraging spatial multiomics to unravel tissue architecture in embryo development

Trends Genet. 2024 Dec 7:S0168-9525(24)00271-3. doi: 10.1016/j.tig.2024.11.007. Online ahead of print.

Authors

Fuqing Jiang¹, Haoxian Wang¹, Zhuxia Li¹, Guizhong Cui², Guangdun Peng³

Affiliations

¹ Center for Cell Lineage Technology and Bioengineering, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, China-New Zealand Belt and Road Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
² Guangzhou Laboratory, Guangzhou, China.
³ Center for Cell Lineage Technology and Bioengineering, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, China-New Zealand Belt and Road Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address: peng_guangdun@gibh.ac.cn.

PMID: 39648060
DOI: 10.1016/j.tig.2024.11.007

Abstract

Spatial multiomics technologies have revolutionized biomedical research by enabling the simultaneous measurement of multiple omics modalities within intact tissue sections. This approach facilitates the reconstruction of 3D molecular architectures, providing unprecedented insights into complex cellular interactions and the intricate organization of biological systems, such as those underlying embryonic development.