The emerging role of Rab proteins in osteoclast organelle biogenesis and function

Shiou-Ling Lu; Takeshi Noda

doi:10.1042/BST20240519

The emerging role of Rab proteins in osteoclast organelle biogenesis and function

Biochem Soc Trans. 2024 Dec 6:BST20240519. doi: 10.1042/BST20240519. Online ahead of print.

Authors

Shiou-Ling Lu¹, Takeshi Noda^{1

2}

Affiliations

¹ Department of Oral Cellular Biology, Center for Frontier Oral Science, Graduate School of Dentistry, Osaka University, Osaka, Japan.
² Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.

PMID: 39641593
DOI: 10.1042/BST20240519

Abstract

Rab GTPase proteins have been extensively studied for their roles in regulating vesicle and organelle dynamics. Among the ∼60 subtypes in mammalian cells, several Rabs have been reported to play crucial roles in osteoclast biogenesis and function. In this review, we aim to provide an update on recently described Rab GTPases, Rab11, Rab32, Rab44, and Rab38, as well as Rab7, Rab3D and Rab27A in osteoclast formation and function.

Keywords: G-proteins; lysosomes; osteogenesis.