Coordination-Assisted Ni-Catalyzed Regio- and Enantioselective 1,2-Borylalkylation of Unactivated Alkenes

Org Lett. 2024 Dec 4. doi: 10.1021/acs.orglett.4c03791. Online ahead of print.

Abstract

Herein we successfully utilize various directing groups to achieve a ligand-enabled nickel-catalyzed 1,2-borylalkylation of unactivated alkenes. A β-amino alcohol was employed as the ligand for non-asymmetric 1,2-borylalkylation of unactivated alkenes, while a bulky chiral diamine ligand was used to achieve the asymmetric 1,2-borylalkylation of allyl amides.