Roles of core fucosylation modification in immune system and diseases

Qiu Pan; Xiao-Lian Zhang

doi:10.1016/j.cellin.2024.100211

Roles of core fucosylation modification in immune system and diseases

Cell Insight. 2024 Oct 9;4(1):100211. doi: 10.1016/j.cellin.2024.100211. eCollection 2025 Feb.

Authors

Qiu Pan^{1

2}, Xiao-Lian Zhang^{1

2}

Affiliations

¹ Hubei Province Key Laboratory of Allergy and Immunology, Department of Allergy Zhongnan Hospital of Wuhan University, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, 430071, China.
² State Key Laboratory of Virology, Frontier Science Center for Immunology and Metabolism, Wuhan University School of Medicine, Wuhan, 430071, China.

Abstract

Core fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals. Research over the past three decades has revealed the critical role of FUT8-mediated core fucosylation modification in various physiological and pathological processes, including cell growth, adhesion, receptor activation, antibody-dependent cellular cytotoxicity (ADCC), tumor metastasis and infections. This review discusses the immune system function involving FUT8 and the mechanisms by which core fucosylation regulates immunity and contributes to disease. A deeper understanding of these mechanisms can provide insights into cellular biology and suggest new therapeutic approaches and targets for related diseases.

Keywords: Core fucosylation; Disease; FUT8; Immune system.

Publication types

Review