Collagen (peptide) extracted from sturgeon swim bladder: Physicochemical characterization and protective effects on cyclophosphamide-induced premature ovarian failure in mice

Mingyi Zhang; Ting Chen; Jiaruo Hu; Weidong Zhang; Mingyue Shen; Qiang Yu; Yi Chen; Jianhua Xie

doi:10.1016/j.foodchem.2024.142217

Collagen (peptide) extracted from sturgeon swim bladder: Physicochemical characterization and protective effects on cyclophosphamide-induced premature ovarian failure in mice

Food Chem. 2024 Nov 23:466:142217. doi: 10.1016/j.foodchem.2024.142217. Online ahead of print.

Authors

Mingyi Zhang¹, Ting Chen¹, Jiaruo Hu¹, Weidong Zhang¹, Mingyue Shen¹, Qiang Yu¹, Yi Chen¹, Jianhua Xie²

Affiliations

¹ State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.
² State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China. Electronic address: jhxie@ncu.edu.cn.

PMID: 39615355
DOI: 10.1016/j.foodchem.2024.142217

Abstract

Premature ovarian failure (POF) is a common female reproductive disorder, with oxidative damage playing a significant role in its development. Studies had demonstrated the beneficial antioxidant, anti-aging, and other biological properties of swim bladder collagen (peptide). In this study, acid extraction, water extraction, and enzymatic hydrolysis methods were used to extract collagen (peptide) from sturgeon (Acipenser sinensis) swim bladder, all of which exhibited significant antioxidant activity. Moreover, the effects observed in POF mice were enhanced, including an increasing in the number of growing ovarian follicles, regulation of serum hormone levels, and alterations in signaling pathways, as evidenced by the up-regulation of Phosphatidylinositol 3-kinase/Protein Kinase B (PI3K/Akt) and B cell lymphoma-2/ Bcl-associated x protein (Bcl-2/Bax) pathways, alongside the down-regulation of the mitogen-activated protein kinases (MAPK) signaling pathway. Sturgeon swim bladder collagen (peptide) could protect against cyclophosphamide-induced POF in mice, which could be very beneficial in the future advancement of health products.

Keywords: Antioxidant activity; Characterization; Collagen; Premature ovarian failure; Sturgeon swim bladder.