Morphology and Applications of Self-Assembled Peptide Nucleic Acids

Int J Mol Sci. 2024 Nov 19;25(22):12435. doi: 10.3390/ijms252212435.

Abstract

Obtaining new materials by exploiting the self-assembly of biomolecules is a very challenging field. In recent years, short peptides and nucleic acids have been used as scaffolds to produce supramolecular structures for different applications in the biomedical and technological fields. In this review, we will focus on the self-assembly of peptide nucleic acids (PNAs), their conjugates with peptides, or other molecules. We will describe the physical properties of the assembled systems and, where described, the application they were designed for.

Keywords: assembly; fiber; hydrogel; micelle; peptide nucleic acid.

Publication types

  • Review

MeSH terms

  • Humans
  • Peptide Nucleic Acids* / chemistry
  • Peptides / chemistry

Substances

  • Peptide Nucleic Acids
  • Peptides

Grants and funding

This research received no external funding.