Characterisation of cytochrome c oxidase-coding genes from mung bean and their response to cadmium stress based on genome-wide identification and transcriptome analysis

Mol Biol Rep. 2024 Nov 26;52(1):17. doi: 10.1007/s11033-024-10102-w.

Abstract

Background: Cytochrome c oxidase (COX) is a crucial mitochondrial enzyme in the electron transport chain of plants, implicated in energy production and stress responses. Despite its importance, the function of COX in leguminous plants, especially under heavy metal stress like cadmium (Cd), remains understudied.

Methods and results: In this study, COX genes (COX s) were identified based on the genome annotation file in mung bean (Vigna radiata (Linn.) R. Wilczek), and the gene structure, physicochemical properties and systematic relationships of the relevant amino acid sequences were analyzed by using bioinformatics method. The effects of Cd on the transcription levels and activities of COX in mung bean roots, stems, and leaves were detected to understand the mechanism of COX in mung bean in response to cadmium (Cd) stress. Transcriptome sequencing revealed tissue-specific expression with roots showed the highest levels. Cd stress significantly altered the expression and activity of VrCOXs, particularly in roots and stems, with varied responses among different genes.

Conclusions: The differential response of VrCOX s to Cd stress indicates a role in the plant stress tolerance mechanism. The study provides insights into the function of COXs in legumes and a foundation for further research into Cd tolerance mechanisms, which could be vital for enhancing legume production and ensuring food safety in contaminated environments.

Keywords: Cadmium (Cd) stress; Cytochrome c oxidase; Mung bean; Transcriptome.

MeSH terms

  • Cadmium* / toxicity
  • Electron Transport Complex IV* / genetics
  • Electron Transport Complex IV* / metabolism
  • Fabaceae / genetics
  • Gene Expression Profiling* / methods
  • Gene Expression Regulation, Plant* / drug effects
  • Gene Expression Regulation, Plant* / genetics
  • Genome, Plant / genetics
  • Phylogeny
  • Plant Leaves / drug effects
  • Plant Leaves / genetics
  • Plant Leaves / metabolism
  • Plant Proteins / genetics
  • Plant Proteins / metabolism
  • Plant Roots / drug effects
  • Plant Roots / genetics
  • Stress, Physiological* / genetics
  • Transcriptome / genetics
  • Vigna* / drug effects
  • Vigna* / genetics

Substances

  • Cadmium
  • Electron Transport Complex IV
  • Plant Proteins